Dépouillements

*** / BUTTERS J. E. ; SMART R. G. ; MANN R. E. ; ASBRIDGE M. in Drug and Alcohol Dependence, 80 (2) (2005)

[article]  in Drug and Alcohol Dependence > 80 (2) (2005)  - p.169-175 Titre : *** Titre autre langue : Illicit drug use, alcohol use and problem drinking among infrequent and frequent road ragers Type de document : Périodique Auteurs : BUTTERS J. E. ; SMART R. G. ; MANN R. E. ; ASBRIDGE M. Année de publication : 2005 Article en page(s) : p.169-175 Caractéristiques matérielles : tabl. Langues : Anglais (eng) Mots-clés : Thésaurus FREQUENCE ; PRODUIT ILLICITE ; ALCOOL ; ABUS ; CONDUITE A RISQUE ; CONDUITE DE VEHICULE Résumé : The purpose of this paper is to investigate the relationships between illicit drug and alcohol use, problem drinking, and road rage. Particular attention is devoted to the association between these behaviors and frequent involvement in road rage activities. The data are taken from the 2002 Centre for Addiction and Mental Health (CAMH) Monitor, a representative telephone survey with a sample of 2421 adults aged 18 and older in Ontario. A cluster analysis was performed and analysis of variance procedures were used to test for group differences. The cluster analysis revealed five distinct groups involved in various types of road rage behavior. Frequent road ragers, accounting for 5,3 % of the sample, were involved in the most severe forms of road rage behavior and were most likely (24 %) to report problem drinking and past year cannabis (23, 8 %), cocaine (5,4 %), and ecstasy (10 %) use. These data indicate that illicit drug use and alcohol problems are significantly greater for those involved in the most serious forms of road rage behavior. Further work is needed to identify the mechanisms by which illicit drug use and problem drinking are linked to road rage. (Review's abstract). Cote CIRDD : 806040 Thématique : Drogues illicites Bibliographie : 32 Permalink : http://doc.cirddalsace.fr/index.php?lvl=notice_display&id=6135 [article]

*** / CARISE D. ; GUREL O. ; McLELLAN A. T. ; DUGOSH K. ; KENDIG C. in Drug and Alcohol Dependence, 80 (2) (2005)

[article]  in Drug and Alcohol Dependence > 80 (2) (2005)  - p.177-189 Titre : *** Titre autre langue : Getting patients the services they need using a computer-assisted system for patient assessment and referralÄCASPAR Type de document : Périodique Auteurs : CARISE D. ; GUREL O. ; McLELLAN A. T. ; DUGOSH K. ; KENDIG C. Année de publication : 2005 Article en page(s) : p.177-189 Caractéristiques matérielles : fig., tabl. Langues : Anglais (eng) Mots-clés : Thésaurus USAGER ; METHODE ; TRAITEMENT ; INFORMATIQUE ; ADAPTATION Résumé : The two goals of this technology transfer study were to : (1) increase the number and appropriateness of services received by substance abuse patients, and thereby (2) give clinical meaning and value to research-based assessment information. A software-based Resource Guide was developed to allow counselors to easily identify local resources for referral of their patients to additional clinical and social services. Two hours of training were provided on the use of the guide. It was hoped that this software and training would provide the counselors with a concrete method of linking the Addiction Severity Index (ASI) assessment information on patient problems to appropriate, available community services. We expected improved treatment planning, increased problem services matching, better patient-counselor rapport/satisfaction and better patient-performance during treatment. Data were analyzed from 131 patients of 33 counselors from 9 treatment programs, randomly assigned to 2 groupsÄStandard Assessment (SA) or Enhanced Assessment (EA). Patients of counselors in the EA group (1) had treatment plans that were better matched to their needs, (2) received significantly more and better-matched services than patients in the SA group, and (3) were less likely to leave treatment against medical advice and more likely to complete the full course of treatment than patients of counselors in the SA group. They did not have higher levels of patient satisfaction or helping alliance scores. These findings are discussed with regard to integrating empirically supported procedures into contemporary, community-based substance abuse treatment. (Review's abstract). Cote CIRDD : 806041 Thématique : Drogues illicites Bibliographie : 39 Permalink : http://doc.cirddalsace.fr/index.php?lvl=notice_display&id=6136 [article]

*** / CHERPITEL C. J. ; YE Y. ; MOSKALEWICZ J. ; SWIATKIEWICZ G. in Drug and Alcohol Dependence, 80 (2) (2005)

[article]  in Drug and Alcohol Dependence > 80 (2) (2005)  - p.201-207 Titre : *** Titre autre langue : Screening for alcohol problems in two emergency service samples in Poland : Comparison of the RAPS4, CAGE and AUDIT Type de document : Périodique Auteurs : CHERPITEL C. J. ; YE Y. ; MOSKALEWICZ J. ; SWIATKIEWICZ G. Année de publication : 2005 Article en page(s) : p.201-207 Caractéristiques matérielles : tabl. Langues : Anglais (eng) Mots-clés : Thésaurus METHODE ; DEPENDANCE ; ALCOOL ; QUESTIONNAIRE ; COMPARAISON ; TEST Résumé : Prior research on alcohol-related problems among emergency service patients in Poland found substantial alcohol involvement on the part of injured males, suggesting emergency services may be a productive venue for identifying patients who could benefit from a brief intervention or referral for treatment. Performance of the RAPS4, CAGE and AUDIT against ICD-10 and DSM-IV criteria for alcohol dependence and for alcohol abuse/harmful drinking was compared in probability samples of emergency service patients from two regions of Poland. Sensitivity of the RAPS4 and AUDIT was significantly better than the CAGE for alcohol dependence among males in Warsaw, but specificity was poorer. Among females, although numbers were small, sensitivity for alcohol abuse/harmful drinking and for alcohol dependence or abuse/harmful drinking was significantly better for the RAPS4-QF than for the CAGE or AUDIT at a cut point of 8 across both sites. Performance of the AUDIT at a cut point of 3 was similar to the RAPS4-QF for females. Among males, sensitivity was higher but specificity considerably lower for the RAPS4-QF compared to the CAGE at a cut point of 1 or for the AUDIT at a cut point of 8. Alternate cut points for the AUDIT optimized performance. Findings suggest some regional and gender differences in performance of screening instruments in these Polish samples, but no instrument or cut point is optimal in identifying those with alcohol use disorders. Additional cross-cultural research is needed to evaluate the performance of instruments, especially among females with alcohol use disorders. (Review's abstract). Cote CIRDD : 806043 Thématique : Alcool Bibliographie : 37 Permalink : http://doc.cirddalsace.fr/index.php?lvl=notice_display&id=6137 [article]

*** / CHUNG T. ; MARTIN C. S. in Drug and Alcohol Dependence, 80 (2) (2005)

[article]  in Drug and Alcohol Dependence > 80 (2) (2005)  - p.191-200 Titre : *** Titre autre langue : What were they thinking ? Adolescents' interpretations of DSM-IV alcohol dependence symptom queries and implications for diagnostic validity Type de document : Périodique Auteurs : CHUNG T. ; MARTIN C. S. Année de publication : 2005 Article en page(s) : p.191-200 Caractéristiques matérielles : tabl. Langues : Anglais (eng) Mots-clés : Thésaurus ADOLESCENT ; DEPENDANCE ; ALCOOL ; VALIDITE ; DSM (III,IV) ; DIAGNOSTIC Résumé : Objective : DSM-IV alcohol dependence criteria of tolerance to alcohol and drinking more or longer than intended have relatively high prevalence among youth, and may be vulnerable to false positive symptom assignments that degrade diagnostic validity. We conducted a methodological study of DSM-IV symptom queries used to assess alcohol tolerance and impaired control over drinking to determine potential sources of measurement error. Method : Adolescents recruited from addictions treatment participated in either a focus group (n = 9) or an individual interview (n = 41) to provide data on their interpretation of selected items contained in a semi-structured diagnostic interview. Results : When alcohol tolerance is operationally defined as a change in quantity to obtain the same effect, large individual differences in the change in quantity that represents a high level of tolerance limit the utility of this operational definition as an indicator of dependence. The symptom "drinking more or longer than intended", includes the embedded assumption that a limit on use had been set. Teens, however, typically intended to become intoxicated, rather than to keep to a limit. Conclusions : Adolescents' understanding of symptom queries suggests how validity of DSM-IV alcohol symptoms and diagnoses can be improved through greater attention to developmental considerations affecting assessment. (Review's abstract). Cote CIRDD : 806042 Thématique : Alcool Bibliographie : 39 Permalink : http://doc.cirddalsace.fr/index.php?lvl=notice_display&id=6138 [article]

*** / MCDOWELL D. ; NUNES E. V. ; SERACINI A. M. ; ROTHENBERG J. ; MA G. J. ; PETKOVA E. in Drug and Alcohol Dependence, 80 (2) (2005)

[article]  in Drug and Alcohol Dependence > 80 (2) (2005)  - p.209-221 Titre : *** Titre autre langue : Desipramine treatment of cocaine-dependent patients with depression : a placebo-controlled trial Type de document : Périodique Auteurs : MCDOWELL D. ; NUNES E. V. ; SERACINI A. M. ; ROTHENBERG J. ; MA G. J. ; PETKOVA E. Année de publication : 2005 Article en page(s) : p.209-221 Caractéristiques matérielles : tabl. Langues : Anglais (eng) Mots-clés : Thésaurus DEPENDANCE ; TRAITEMENT ; ANTIDEPRESSEURS ; COCAINE ; COMORBIDITE ; DEPRESSION Résumé : Objective : The aim of this study was to test the hypothesis that desipramine would be an effective treatment in cocaine abusers with current depressive disorders.Method: This was a randomized, 12-week, double-blind, 'placebo-controlled trial of outpatients (N = 111) meeting DSM-III-R criteria for cocaine dependence and major depression or dysthymia (by SCID interview). Participants were treated with desipramine, up to 300 mg per day, or matching placebo. All patients received weekly individual manual-guided relapse prevention therapy. Weekly outcome measures included the Clinical Global Impression Scale, self-reported cocaine use and craving, urine toxicology, and the Hamilton Depression Scale (biweekly). Summary measures of mood and cocaine use outcome were compared between treatment groups with x2-or t-tests. Dichotomous summary measures of depression response and cocaine response were the primary outcomes. Mixed effect models were also fit to explore the relationship of cocaine use to mood improvement and treatment over weeks in the trial. Results : Desipramine was associated with a higher rate of depression response (51 %, 28/55) than placebo (32 %, 18/56) (p < 0,05), but treatment groups did not differ in rate of cocaine response. Depression improvement was associated with improvement in cocaine use. Desipramine was associated with more dropouts due to side effects and medical adverse events, while placebo was associated with more dropouts due to psychiatric worsening. Conclusions : RESUME INCOMPLET. (Review's abstract). Cote CIRDD : 806044 Thématique : Drogues illicites Bibliographie : 37 Permalink : http://doc.cirddalsace.fr/index.php?lvl=notice_display&id=6139 [article]

*** / CHOU S. P. ; GRANT B. F. ; DAWSON D. A. ; STINSON F. S. ; SAHA T. ; PICKERING R. P. in Drug and Alcohol Dependence, 80 (2) (2005)

[article]  in Drug and Alcohol Dependence > 80 (2) (2005)  - p.223-230 Titre : *** Titre autre langue : Twelve-month prevalence and changes in driving after drinking: United States, 1991-1992 and 2001-2002 Type de document : Périodique Auteurs : CHOU S. P. ; GRANT B. F. ; DAWSON D. A. ; STINSON F. S. ; SAHA T. ; PICKERING R. P. Année de publication : 2005 Article en page(s) : p.223-230 Caractéristiques matérielles : tabl. Langues : Anglais (eng) Mots-clés : Thésaurus EVOLUTION ; POPULATION A RISQUE ; PREVALENCE ; ALCOOL ; CONDUITE DE VEHICULE ; COMPORTEMENT Descripteurs géographiques ETATS-UNIS Résumé : Background : Drinking and driving has been identified as one of the most important contributors of motor vehicle fatalities. This paper addressed the existing gap in our public health knowledge regarding the current prevalence of driving after drinking and how this has changed over the past decade. Methods : Prevalence rates of drinking and driving in 2001-2002, and changes in those prevalence rates between 1991-1992 and 2001-2002 were examined in two large nationally representative surveys of the U.S. population. Results : Overall, the prevalence of driving after drinking was 2,9 % in 2001-2002 representing approximately six million U.S. adults. This rate was about three quarters of the rate observed in 1991-1992 (3,7 %), reflecting a 22 % reduction. Generally, the male-female differentials in the rate of driving after drinking decreased over the past decade. However, the sex ratios increased substantially for underaged youth over the past decade, reflecting the sharp decrease in prevalence of driving after drinking among 18-20-year-old women. Constant and emerging subgroups at high risk for drinking and driving included Whites, Native Americans, males, underaged young adults and 21-25-year-olds. Conclusions : The results of this study highlighted the need to continue to monitor prevalence and changes in driving after drinking. Results are discussed in the context of strengthening existing prevention and intervention efforts and developing new programs with the sociodemographic differentials observed in this study in mind. (Review's abstract). Cote CIRDD : 806045 Thématique : Drogues illicites Bibliographie : 31 Permalink : http://doc.cirddalsace.fr/index.php?lvl=notice_display&id=6140 [article]

*** / PARTHASARATHY S. ; WEISNER C. M. in Drug and Alcohol Dependence, 80 (2) (2005)

[article]  in Drug and Alcohol Dependence > 80 (2) (2005)  - p.231-240 Titre : *** Titre autre langue : Five-year trajectories of health care utilization and cost in a drug and alcohol treatment sample Type de document : Périodique Auteurs : PARTHASARATHY S. ; WEISNER C. M. Année de publication : 2005 Article en page(s) : p.231-240 Caractéristiques matérielles : tabl. Langues : Anglais (eng) Mots-clés : Thésaurus PSYCHOTROPES ; DEPENDANCE ; TRAITEMENT ; COUT Résumé : Background : The study examined the effect of individual characteristics on longitudinal patterns of health care utilization and cost among individuals entering chemical dependency (CD) treatment. Method : Structured interviews and computerized administrative databases were linked to obtain severity, utilization and cost data. Total medical costs and their components were examined for the 6 months prior to intake through 5 years post-intake. Statistical analyses were conducted using the hierarchical linear modeling framework. Results : Age was positively correlated with total medical costs. Women had higher inpatient utilization and higher inpatient, primary care and total cost at baseline (p < ,05). However, they had steeper decline in primary care costs. While age was not related to inpatient and ER use at baseline (after controlling for psychiatric and medical severity), older individuals had smaller declines in hospital days and inpatient cost over time. Individuals with high medical and psychiatric severity had higher utilization and costs (p < ,01). Those who were abstinent had higher costs. Conclusions : There are important differences in patient characteristics and treatment outcomes that influence utilization and cost trajectories. The relationship between medical severity at intake and primary care cost pre-intake among patients with drug and alcohol problems suggests an opportunity to identify and treat drug and alcohol problems in primary care settings. It also suggests that medical evaluations and treatment should not be overlooked during CD treatment. The positive association between abstinence and trajectories of primary care and total medical costs suggests that maintaining abstinence over a long term requires some kind of continuing care either in primary care settings or via additional contacts with specialty CD departments. (Review's abstract). Cote CIRDD : 806046 Thématique : Drogues illicites Bibliographie : 57 Permalink : http://doc.cirddalsace.fr/index.php?lvl=notice_display&id=6141 [article]

*** / STOR C. L. ; REBOUSSIN B. A. ; ANTHONY J. C. in Drug and Alcohol Dependence, 80 (2) (2005)

[article]  in Drug and Alcohol Dependence > 80 (2) (2005)  - p.241-250 Titre : *** Titre autre langue : The Fagerström test for nicotine dependence : a comparison of standard scoring and latent class analysis approaches Type de document : Périodique Auteurs : STOR C. L. ; REBOUSSIN B. A. ; ANTHONY J. C. Année de publication : 2005 Article en page(s) : p.241-250 Caractéristiques matérielles : tabl. Langues : Anglais (eng) Mots-clés : Thésaurus EVALUATION ; DEPENDANCE ; TABAC ; TEST Résumé : The classification of being tobacco dependent obtained via the established scoring method of the Fagerström test for nicotine dependence (FTND) is compared to a method that bases classification on the pattern of item responses. Young adults participating in a longitudinal study, who indicated they had ever smoked, were asked six standardized items (n = 962; mean age 21 years). By standard scoring, the mean FTND score was 1,9 (S.E. = 2,3) : 66 % of the smokers qualified for a very low level of dependence, 17 % low, 9 % moderate, and 9 % a high level of dependence. Response patterns detected by latent class analysis (LCA) indicated class differences based on severity gradations and of qualitative content. Three profiles of tobacco dependence were found : a non-dependent class (50 %), a class manifesting a moderate number of dependence features (31 %), and more severely affected class (19 %). The vast majority of smokers (three-fourth) were classified congruently by these two methods. Discrepancies involved LCA classifying smokers into a higher level of dependence when compared to the conventional scoring classification. Patterns of dependence features obtained from population samples that include a wide range of smokers may provide insight into possible phenotypic differences among tobacco smokers, particularly when LCA methods are used to complement standard scoring methods. (Review's abstract). Cote CIRDD : 806047 Thématique : Tabac Bibliographie : 35 Permalink : http://doc.cirddalsace.fr/index.php?lvl=notice_display&id=6142 [article]

*** / KOLODZIEJ M. ; GRIFFIN M. L. ; NAJAVITS L. M. ; OTTO M. W. ; GREENFIELD S. F. ; WEISS R. D. in Drug and Alcohol Dependence, 80 (2) (2005)

[article]  in Drug and Alcohol Dependence > 80 (2) (2005)  - p.251-257 Titre : *** Titre autre langue : Anxiety disorders among patients with co-occurring bipolar and substance use disorders Type de document : Périodique Auteurs : KOLODZIEJ M. ; GRIFFIN M. L. ; NAJAVITS L. M. ; OTTO M. W. ; GREENFIELD S. F. ; WEISS R. D. Année de publication : 2005 Article en page(s) : p.251-257 Caractéristiques matérielles : tabl. Langues : Anglais (eng) Mots-clés : Thésaurus DEPENDANCE ; ANXIETE ; COMORBIDITE Résumé : Bipolar and substance use disorders are known to co-occur frequently, but limited attention has been paid to anxiety disorders that may accompany this dual diagnosis. Therefore, we examined the prevalence and nature of anxiety disorders among treatment-seeking patients diagnosed with current bipolar and substance use disorders, and investigated the association between anxiety disorders and substance use. Among 90 participants diagnosed with bipolar disorder I (n = 75, 78 %) or II (n = 15, 22 %), 43 (48 %) had a lifetime anxiety disorder, with post-traumatic stress disorder (PTSD) occurring most frequently (n = 21, 23 %). We found that those with PTSD, but not with the other anxiety disorders assessed, began using drugs at an earlier age and had more lifetime substance use disorders, particularly cocaine and amphetamine use disorders, than those without PTSD. Further examination revealed that (1) most participants with PTSD were women, (2) sexual abuse was the most frequently reported index trauma, and (3) the mean age of the earliest index trauma occurred before the mean age of initiation of drug use. Our findings point to the importance of further investigating the ramifications of a trauma history among those who are dually diagnosed with bipolar and substance use disorders. (Review's abstract). Cote CIRDD : 806048 Thématique : Drogues illicites Bibliographie : 35 Permalink : http://doc.cirddalsace.fr/index.php?lvl=notice_display&id=6143 [article]

*** / TIDEY J. W. ; ROHSENOW D. ; KAPLAN G. B. ; SWIFT R. M. in Drug and Alcohol Dependence, 80 (2) (2005)

[article]  in Drug and Alcohol Dependence > 80 (2) (2005)  - p.259-265 Titre : *** Titre autre langue : Cigarette smoking topography in smokers with schizophrenia and matched non-psychiatric controls Type de document : Périodique Auteurs : TIDEY J. W. ; ROHSENOW D. ; KAPLAN G. B. ; SWIFT R. M. Année de publication : 2005 Article en page(s) : p.259-265 Caractéristiques matérielles : tabl. Langues : Anglais (eng) Mots-clés : Thésaurus DEPENDANCE ; SCHIZOPHRENIE ; TABAC Résumé : Smoking is highly prevalent among people with schizophrenia, and little is known about factors that affect smoking in these patients. One basic question is whether smoking behavior differs for smokers with schizophrenia compared to equally nicotine-dependent smokers who do not have a major mental illness. In this study, 20 smokers with schizophrenia or schizoaffective disorder (SCZ) and 20 non-psychiatric smokers (CON) underwent smoking topography assessments. The groups were matched on age, gender, daily smoking rate, years of regular smoking and nicotine dependence rating. Results indicate that, compared to the CON participants, the SCZ participants smoked significantly more total puffs (SCZ: 58.5 + 48.3 ; CON : 21,3 + 9,4) and puffs per cigarette (SCZ : 12,3 + 6,0 ; CON : 8,9 + 2,3) and had shorter inter-puff intervals (SCZ : 21,9 + 9,7 s ; CON : 42,0 + 21,5 s), larger total cigarette puff volumes (SCZ : 583 + 169 ml ; CON : 429 + 159 ml) and higher carbon monoxide boosts (SCZ : 3,8 + 5,4 ppm ; CON : 1,0 + 2,5 ppm). Test-retest reliabilities were good to excellent for most smoking measures in both groups. These findings suggest that smokers with schizophrenia smoke more intensely than matched non-psychiatric smokers and that their smoking behavior is reliable when assessed under laboratory conditions. (Review's abstract). Cote CIRDD : 806049 Thématique : Tabac Bibliographie : 48 Permalink : http://doc.cirddalsace.fr/index.php?lvl=notice_display&id=6144 [article]

*** / VERTHEIN U. ; ULLMANN R. ; LACHMANN A. ; DURING A. ; KOCH B. ; MEYER-THOMPSON H. G. ; SCHMIDT R. ; REIMER J. ; HAASEN C. in Drug and Alcohol Dependence, 80 (2) (2005)

[article]  in Drug and Alcohol Dependence > 80 (2) (2005)  - p.267-271 Titre : *** Titre autre langue : The effects of racemic D,L-methadone and L-methadone in substituted patientsÄa randomized controlled study Type de document : Périodique Auteurs : VERTHEIN U. ; ULLMANN R. ; LACHMANN A. ; DURING A. ; KOCH B. ; MEYER-THOMPSON H. G. ; SCHMIDT R. ; REIMER J. ; HAASEN C. Année de publication : 2005 Article en page(s) : p.267-271 Caractéristiques matérielles : fig., tabl. Langues : Anglais (eng) Mots-clés : Thésaurus MECANISME D'ACTION ; METHADONE ; BIOCHIMIE Résumé : Aims : To test the hypothesis that switching from L-methadone to D,L-methadone is associated with more frequent withdrawal symptoms and side-effects than switching from D,L-methadone to L-methadone. Design : Stratified, randomized 2 x 2 crossover study design over a time-period of 8 weeks. At study entry, every second patient was switched from the pre-study substance to the other medication, after 4 weeks all patients were subject to a (re-)switch. Setting : The study was conducted as a multi-centre trial in three methadone maintenance therapy (MMT) clinics. Participants : Seventy-five patients previously treated with either d,l-methadone or l-methadone for at least 1 year took part in the study. Measurements : Intra-individual changes in withdrawal symptoms (Short Opiate Withdrawal Scale, SOWS) and side-effects were defined as primary outcome criteria. Secondary outcome measures included necessity for methadone dose adjustment.Findings : Complete data were available for 68 patients (91 %). Sample strata were unbalanced at baseline : 15 patients (22 %) were treated with L-methadone and 43 with D,L-methadone (78 %). Thirty-five patients were randomized into the group treated with l-methadone and 33 into the group treated with D,L-methadone during the first 4 weeks. There were no significant differences in intra-individual change of withdrawal symptoms and side-effects between groups after crossover. However, patients treated with levomethadone tended to feel less withdrawal symptoms than patients treated with D,L-methadone. Conclusions : D,L-methadone and L-methadone can safely be replaced by each other on a 2 : 1 ratio. Withdrawal symptoms or side-effects due to conversion are of transient nature only. (Review's abstract). Cote CIRDD : 806050 Thématique : Drogues illicites Bibliographie : 12 Permalink : http://doc.cirddalsace.fr/index.php?lvl=notice_display&id=6145 [article]

*** / ZACNY J. P. in Drug and Alcohol Dependence, 80 (2) (2005)

[article]  in Drug and Alcohol Dependence > 80 (2) (2005)  - p.273-278 Titre : *** Titre autre langue : Profiling the subjective, psychomotor, and physiological effects of tramadol in recreational drug users Type de document : Périodique Auteurs : ZACNY J. P. Année de publication : 2005 Article en page(s) : p.273-278 Caractéristiques matérielles : tabl. Langues : Anglais (eng) Mots-clés : Thésaurus USAGE RECREATIF ; POTENTIEL ADDICTIF ; ANTALGIQUES ; OPIACES Résumé : Tramadol is a mu opioid agonist that also inhibits the reuptake of norepinephrine and serotonin. Because non-medical use of prescription opioids, including tramadol, has increased in the U.S. over the last several years, we sought to profile its subjective, psychomotor, and physiological effects in recreational drug users. Twenty-two subjects received placebo, 50 or 100 mg tramadol, morphine, or 2 mg lorazepam in a randomized, crossover, double-blind design. The last 12 subjects in the study received 25 mg morphine, a dose that is putatively equianalgesic to 100 mg tramadol. In these subjects, morphine induced miosis and several other mu agonist subjective effects ; 100 mg tramadol increased "feel drug effect" and drug liking ratings, and decreased pupil size, but the miotic effect was not statistically significant. Lorazepam, but neither tramadol nor morphine, impaired psychomotor performance. When the placebo, tramadol, and lorazepam data from all 22 subjects were analyzed, 100 mg tramadol induced miosis, and several subjective effects were increased significantly, including ratings of drug liking and "want to take again". The present results indicating that a clinically-prescribed dose of oral tramadol has abuse liability-related effects in recreational drug users suggest the need for further abuse liability testing of the oral formulation in opioid abusers. (Review's abstract). Cote CIRDD : 806051 Thématique : Drogues illicites Bibliographie : 35 Permalink : http://doc.cirddalsace.fr/index.php?lvl=notice_display&id=6146 [article]

(Améliorer le traitement de la dépendance au cannbais. Revue des principales médications potentielles) / HART C. L. in Drug and Alcohol Dependence, 80 (2) (2005)

[article]  in Drug and Alcohol Dependence > 80 (2) (2005)  - p.147-159 Titre : (Améliorer le traitement de la dépendance au cannbais. Revue des principales médications potentielles) Titre autre langue : Increasing treatment options for cannabis dependence : a review of potential pharmacotherapies Type de document : Périodique Auteurs : HART C. L. Année de publication : 2005 Article en page(s) : p.147-159 Langues : Anglais (eng) Mots-clés : Thésaurus DEPENDANCE ; RECHERCHE ; ANTAGONISTE ; CANNABIS ; SEVRAGE Cote CIRDD : 805364 Thématique : Drogues illicites Bibliographie : 90 Permalink : http://doc.cirddalsace.fr/index.php?lvl=notice_display&id=6784 [article]

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